360° Coverage : Tweaked protein prevents diastolic heart failure

Tweaked protein prevents diastolic heart failure

Washington, Feb 11 (IANS) Researchers have identified and tweaked a specific protein molecule, parvalbumin, to prevent diastolic heart failure when its pumping mechanism goes haywire.

Feb 11 2013, 4:18am CST | by

Tweaked protein prevents diastolic heart failure
Photo Credit: Leigh Vogel, Getty Images

Washington, Feb 11 — Researchers have identified and tweaked a specific protein molecule, parvalbumin, to prevent diastolic heart failure when its pumping mechanism goes haywire.

Diastolic heart failure arises when peak calcium levels, required for heart's sqeezing action, don't drop off quickly enough to permit the organ to relax. Then the lower left heart chamber (left ventricle) does not fill with enough blood to be pumped out to the body.

University of Minnesota researchers, led by Joseph M. Metzger, professor of integrative biology and physiology, optimised the parvalbumin protein as ParvE101Q, to soak up excess calcium at a precise instant, allowing the heart to relax efficiently after contraction, the journal Nature Medicine reports.

The advance offers a solid conceptual step forward in solving the puzzle of diastolic heart failure.

The next step will be determining the best possible small molecule or gene delivery mechanism for the protein, which should allow the discovery to be used in clinics, according to a Minnesota statement.

"We've discovered that our optimised variation of parvalbumin can fulfil that role by treating diastolic heart failure," adds Metzger.

The researchers believe they may have found a unique clinical application to treat diastolic heart failure.

"Heart disease and heart failure rates are growing, especially as our population ages. We hope this type of discovery may one day help pave the way to a better way to treat patients," said Metzger.

IANS

Source: IANS

 
 
 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

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