360° Coverage : Drug shows promise in busting Hepatitis C virus

6 Updates
Drug shows promise in busting Hepatitis C virus
Photo Credit: Ian Gavan, Getty Images

Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy...

Filed under: news

YouTube Videos

 
 
 

1 year ago

Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Daclatasvir, a direct acting antiviral (DAA) agent, targets one of the HCV proteins NS5A and causes the fastest viral decline, within 12 hours of treatment ever seen with anti-HCV drugs.

An interdisciplinary effort by mathematical modellers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life, the journal Proceedings of the National Academy of Sciences reports.

"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeller Harel Dahari, who co-led the study.

Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, who authored the study with Thomas Layden, HCV virologist Susan L. Uprichard and her doctoral graduate student Natasha Sansone, according to a Loyola statement.

"Daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also secretion of infectious virus from the cells," said Dahari.

This prediction was confirmed in Uprichard's lab using cultured liver cells that support the entire life cycle of HCV infection.

IANS

Source: IANS

 
Update
6

1 week ago

Health Exchange: Gilead’s new drug is even pricier than Sovaldi

Oct 10 2014 2:12pm CDT | Source: MarketWatch

Gilead’s new hepatitis C drug is even pricier than its $1,000-a-day Sovaldi. ...
Source: MarketWatch   Full article at: MarketWatch
 

 
Update
5

1 week ago

Harvoni, a Hepatitis C Drug From Gilead, Wins F.D.A. Approval

Oct 10 2014 1:45pm CDT | Source: NewYorkTimes-Business Day

The drug is the first complete treatment for the disease that requires a single da ...
Source: NewYorkTimes-Business Day   Full article at: NewYorkTimes-Business Day
 

 
Update
4

1 week ago

Biotron shares soar on Hep C trial data

Oct 9 2014 8:53pm CDT | Source: NEWS.com.au

SHARES in drug developer Biotron have soared 75 per cent after trial data suggested it may have found a potential cure for ...
Source: NEWS.com.au   Full article at: NEWS.com.au
 

 
Update
3

1 week ago

The Wall Street Journal: Bristol-Myers drops Hepatitis C dual regimen in U.S.

Oct 7 2014 10:15am CDT | Source: MarketWatch

Company will not pursue FDA approval amid ‘rapidly evolving’ treatment landscape. ...
Source: MarketWatch   Full article at: MarketWatch
 

 
Update
2

4 weeks ago

One In 12 Hepatitis C Patients Not Adhering To $1,000/Day Pill

Sep 17 2014 9:22pm CDT | Source: Forbes Real Time

Why would someone stop using a $30,000 bottle of medicine with few side effects and a 95% cure ra ...
Source: Forbes Real Time   Full article at: Forbes Real Time
 

 

Don't miss ...

 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

blog comments powered by Disqus

Latest stories

UN chief seeks more efforts for Millenium Development Goals
United Nations, Oct 21 (IANS) UN Secretary-General Ban Ki-moon has called on the scientific community to invest more talent and resources to research that would contribute to UN' s Millennium Development Goals (MDGs).
 
 
EU to intensify efforts against Ebola
Brussels, Oct 21 (IANS) The European Union (EU) has decided to intensify efforts to protect its citizens, health workers against the ongoing spread of the Ebola virus in West Africa.
 
 
Germany, France agree to boost investment
Berlin, Oct 21 (IANS) Germany and France have agreed to strengthen investment for the euro zone economy.
 
 
EU strengthens sanctions against Syria
Brussels, Oct 21 (IANS) The European Union (EU) Monday announced it was strengthening sanctions against Syria.
 
 
 

Latest from the Network

1,074 new dengue cases in Chinese province
Beijing, Oct 18 (IANS) China's Guangdong province has reported 1,047 new cases of dengue fever, health authorities said Saturday. Six people have already died in Guangdong -- five in Guangzhou and one in adjacent...
Read more on Business Balla
 
Blake Lively 'always' wanted to be mum
Blake Lively has ''always'' wanted to be a mother. The 27-year-old actress is expecting her first child with husband Ryan Reynolds and she admits she's been dreaming of this moment since she was a youngster. Speaking...
Read more on Celebrity Balla
 
Kris Jenner 'torn apart' by Bruce's new relationship
Kris Jenner feels ''torn apart and angry'' that Bruce Jenner is dating her former assistant. The 58-year-old matriarch split from the 64-year-old Olympic gold medalist last October following 22-years of marriage but is...
Read more on Celebrity Balla
 
Cheryl Fernandez-Versini won't move to France
Cheryl Fernandez-Versini doesn't want to move to her husband's home country of France. The 'X Factor' judge, 31, who comes from Newcastle, is adamant she won't be relocating any time soon to suit her new spouse Jean-...
Read more on Celebrity Balla
 
Lance Bass sets wedding date
Lance Bass has set a date for his wedding. The former *NSYNC singer and his partner Michael Turchin, who have been dating for two-and-a-half years, are to tie the knot on December 20, 2014, a representative for the...
Read more on Celebrity Balla
 
Nepal avalanche toll reaches 39
Kathmandu, Oct 18 (IANS) At least 39 climbers died while hiking on a key Nepali route after it was hit by a major snowstorm and avalanches earlier this week, BBC reported Saturday citing officials. Over 350 stranded...
Read more on Politics Balla
 
Jake Gyllenhaal says society is complicit in 'nightcrawling'
Jake Gyllenhaal says almost everybody in society ought to relate to his new movie 'Nightcrawlers'. The eagerly-awaited film concerns those people who monitor police scanners and then race to crime scenes to film eye-...
Read more on Movie Balla
 
India eves look for first win in AFC U-16 qualifiers
Dhaka, Oct 18 (IANS) India will hope to register their first win of the 2015 Asian Football Confederation (AFC) Under-16 Women's Championship qualifiers when they take on hosts Bangladesh in a crucial encounter at the...
Read more on Sport Balla
 
Moyes mulling return to management
London, Oct 18 (IANS) Former Manchester United manager David Moyes said that he is ready to revive his managerial career six months after being sacked by the 'Red Devils'. "I am ready to return. I have enjoyed the...
Read more on Sport Balla
 
Ebola fears loom over Ghana hosting AFCON
Accra (Ghana), Oct 18 (IANS) The Ghana Medical Association (GMA) cautioned the government Saturday against hosting the 2015 African Cup of Nations (AFCON), despite a request by the Confederation of African Football (...
Read more on Sport Balla