8 Updates
Drug shows promise in busting Hepatitis C virus
Photo Credit: Ian Gavan, Getty Images

Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy...

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1 year ago

Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Daclatasvir, a direct acting antiviral (DAA) agent, targets one of the HCV proteins NS5A and causes the fastest viral decline, within 12 hours of treatment ever seen with anti-HCV drugs.

An interdisciplinary effort by mathematical modellers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life, the journal Proceedings of the National Academy of Sciences reports.

"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeller Harel Dahari, who co-led the study.

Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, who authored the study with Thomas Layden, HCV virologist Susan L. Uprichard and her doctoral graduate student Natasha Sansone, according to a Loyola statement.

"Daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also secretion of infectious virus from the cells," said Dahari.

This prediction was confirmed in Uprichard's lab using cultured liver cells that support the entire life cycle of HCV infection.

IANS

Source: IANS

 
Update
8

5 days ago

Sovaldi—$55 billion headache for states

Jul 17 2014 9:18am CDT | Source: CNBC

The Hepatitis C Trust's Bingo Night At The Groucho
States may be on the hook for $55 billion to pay for hepatitis C treatments like Sovaldi, a new ...
Source: CNBC   Full article at: CNBC
 

 
Update
7

5 weeks ago

Why Did Merck Pay Such A Huge Premium For Idenix?

Jun 12 2014 7:36am CDT | Source: Forbes Real Time

Deutsche Bank
The essence is that there is a lot of potential. The demand is high as close to 150 million people suffer from Hepatitis C globally. The overall market for Hepatitis C treatment could reach $20 billion by 2020 and Gilead Sciences could capture around 80% of this market acc ...
Source: Forbes Real Time   Full article at: Forbes Real Time
 

 
Update
6

6 weeks ago

Merck challenges Gilead with $3.85B hepatitis C acquisition

Jun 9 2014 3:31pm CDT | Source: Mercury News

Bayern AG To Buy Merck's Consumer Unit For 14 Billion
Merck will spend about $3.85 billion for Idenix Pharmaceuticals, a small company developing hepatitis C medicines that, together with Merck's experimental drugs, could produce lucrative combo therapies that quickly cure most patients with the blood-borne virus afflic ...
Source: Mercury News   Full article at: Mercury News
 

 
Update
5

7 weeks ago

At $1,000 per pill, Gilead's hepatitis C drug has insurers, others scratching their heads

May 30 2014 3:03pm CDT | Source: San Francisco Business Times

The Hepatitis C Trust's Bingo Night At The Groucho
A new “miracle drug” is raising eyebrows across the health universe not because of its ability to cure hepatitis C, but because of its price tag. At $1,000 per pill, Sovaldi has Oregon insurers, both in the public and private spheres, scrambling to figure out if and when to cover the treatment. “Like so many people all across this country, we’re in the middle of evaluating both the efficacy of current screening options for hepatiti ...
Source: San Francisco Business Times   Full article at: San Francisco Business Times
 

 
Update
4

7 weeks ago

At $1,000 per pill, new Hepatitis C drug has insurers and CCOs scratching their heads

May 29 2014 3:48pm CDT | Source: Business Journal of Portland

The Hepatitis C Trust's Bingo Night At The Groucho
A new “miracle drug” is raising eyebrows across the health universe not because of its ability to cure Hepatitis C, but because of its price tag. At $1,000 per pill, Sovaldi has Oregon insurers, both in the public and private spheres, scrambling to figure out if and when to cover the treatment. “Like so many people all across this country, we’re in the middle of evaluating both the efficacy of current screening options for hepati ...
Source: Business Journal of Portland   Full article at: Business Journal of Portland
 

 
Update
2

7 weeks ago

The Price is Right: New Hepatitis C Drug is Really a Priceless Breakthrough

May 28 2014 2:37pm CDT | Source: Forbes Real Time

The Hepatitis C Trust's Bingo Night At The Groucho
Before the invention of Solvadi, no amount of money could have made it available. It was priceless. To bemoan its cost is to denigrate the minds of those who made such a product a ...
Source: Forbes Real Time   Full article at: Forbes Real Time
 

 
Update
1

8 weeks ago

What the Hepatitis Scare Means For Red Robin Burgers

May 24 2014 9:17am CDT | Source: Fool.com

The Hepatitis C Trust's Bingo Night At The Groucho
An infected worker at a Missouri restaurant could have exposed as many as 5,000 customers to the virus. ...
Source: Fool.com   Full article at: Fool.com
 

 

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<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

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