360° Coverage : Drug shows promise in busting Hepatitis C virus

7 Updates
Drug shows promise in busting Hepatitis C virus
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Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy...

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1 year ago

Drug shows promise in busting Hepatitis C virus

Feb 19 2013, 5:26am CST | by

Washington, Feb 19 (IANS) Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Washington, Feb 19 — Hepatitis C virus (HCV) infection affects about 4.1 million people in the United States alone and is the primary cause of liver cirrhosis and liver cancer. Current therapy against the infection is not particularly effective.

Daclatasvir, a direct acting antiviral (DAA) agent, targets one of the HCV proteins NS5A and causes the fastest viral decline, within 12 hours of treatment ever seen with anti-HCV drugs.

An interdisciplinary effort by mathematical modellers, clinicians and molecular virologists has revealed that daclatasvir has two main modes of action against HCV and also yields a new, more accurate estimate of the HCV half-life, the journal Proceedings of the National Academy of Sciences reports.

"Ultimately, our study will help design better DAA drug cocktails to treat HCV," said Loyola University Health System (LUHS) and Stritch School of Medicine (SSOM) mathematical modeller Harel Dahari, who co-led the study.

Dahari is one of five members of the Division of Hepatology at Loyola headed by Scott Cotler, who authored the study with Thomas Layden, HCV virologist Susan L. Uprichard and her doctoral graduate student Natasha Sansone, according to a Loyola statement.

"Daclatasvir not only blocks the synthesis of the viral RNA within infected cells but also secretion of infectious virus from the cells," said Dahari.

This prediction was confirmed in Uprichard's lab using cultured liver cells that support the entire life cycle of HCV infection.

IANS

Source: IANS

 
Update
7

1 week ago

Miracle cures spur demand for access to Gilead's $1,000 hepatitis pill

Jul 25 2014 10:10pm CDT | Source: Mercury News

The powerful new hepatitis C drug that sent Gilead Science's sales soaring this year is doing the same for the hopes of millions of ...
Source: Mercury News   Full article at: Mercury News
 

 
Update
6

1 week ago

Trillium Health Holds Free Hepatitis C Clinic on Monroe Avenue

Jul 25 2014 6:49pm CDT | Source: Your News Now - Finger Lakes

Hepatitis C is a serious and potentially deadly disease that disproportionately affects the African-American com ...
Source: Your News Now - Finger Lakes   Full article at: Your News Now - Finger Lakes
 

 
Update
5

1 week ago

Gilead Sciences Crushes Second-Quarter Earnings

Jul 23 2014 7:30pm CDT | Source: Fool.com

Gilead's new hepatitis C drug, Sovaldi, helps propels a gigantic earnings beat in the secon ...
Source: Fool.com   Full article at: Fool.com
 

 
Update
4

2 weeks ago

Sovaldi—$55 billion headache for states

Jul 17 2014 9:18am CDT | Source: CNBC

States may be on the hook for $55 billion to pay for hepatitis C treatments like Sovaldi, a new stud ...
Source: CNBC   Full article at: CNBC
 

 
Update
3

7 weeks ago

Why Did Merck Pay Such A Huge Premium For Idenix?

Jun 12 2014 7:36am CDT | Source: Forbes Real Time

The essence is that there is a lot of potential. The demand is high as close to 150 million people suffer from Hepatitis C globally. The overall market for Hepatitis C treatment could reach $20 billion by 2020 and Gilead Sciences could capture around 80% of this market according to Deutsche Bank, unless viable alte ...
Source: Forbes Real Time   Full article at: Forbes Real Time
 

 
Update
1

7 weeks ago

Merck challenges Gilead with $3.85B hepatitis C acquisition

Jun 9 2014 3:31pm CDT | Source: Mercury News

Merck will spend about $3.85 billion for Idenix Pharmaceuticals, a small company developing hepatitis C medicines that, together with Merck's experimental drugs, could produce lucrative combo therapies that quickly cure most patients with the blood-borne virus afflicting tens of mil ...
Source: Mercury News   Full article at: Mercury News
 

 

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<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

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