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Painkiller receptor variant developed

Los Angeles, June 17 (IANS) Researchers have developed a variant of a major painkiller receptor that enables scientists to perform experiments previously deemed difficult or impossible, says a study.

Jun 17 2013, 3:28am CDT | by

Painkiller receptor variant developed
Photo Credit: Drew Hallowell, Getty Images

Los Angeles, June 17 — Researchers have developed a variant of a major painkiller receptor that enables scientists to perform experiments previously deemed difficult or impossible, says a study.

An interdisciplinary group of researchers at the University of Pennsylvania has developed a variant of the mu opioid receptor that has several advantages when it comes to experimentation.

This variant can be grown in large quantities in bacteria and is also water-soluble, enabling experiments and applications that had previously been very challenging or impossible, reports Science Daily.

The study was led by Renyu Liu, assistant professor in the Department of Anaesthesiology and Critical Care at Penn's Perelman School of Medicine, and Jeffery Saven, associate professor in the Department of Chemistry in the School of Arts and Sciences.

The research was published in the Journal PLOS ONE.

The mu opioid receptor belongs to a class of cellular membrane proteins called G protein-coupled receptors, or GPCRs. Involved in wide range of biological processes, these receptors bind to molecules in the environment, initiating cellular signalling pathways.

In the case of this receptor, binding to opioid molecules leads to a profound reduction of pain but also to a variety of unpleasant and potentially fatal side-effects, a problem that researchers from multiple disciplines are attempting to address.

"There are two directions for solving this problem in basic science, either working on the opioid molecule or working on the receptor," Liu said. "We're doing the latter."

IANS

Source: IANS

 
 
 

<a href="/latest_stories/all/all/8" rel="author">Luigi Lugmayr</a>
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at ml@i4u.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.

 

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