10 Updates

Low T Or High Risk? Testosterone Treatments And Heart Attacks

Jan 29 2014, 10:52pm CST | by

Maybe ‘Low T’ is something men may want to live with, after all. A new study finds that treatments for boosting low testosterone levels – which pervasive marketing warns can interfere with sex drive...

Filed under: news

 
 
 

25 weeks ago

Low T Or High Risk? Testosterone Treatments And Heart Attacks

Jan 29 2014, 10:52pm CST | by

Maybe ‘Low T’ is something men may want to live with, after all. A new study finds that treatments for boosting low testosterone levels – which pervasive marketing warns can interfere with sex drive, moods and energy – may increase the risk of heart attacks in large swathes of men.

Specifically, the risk doubled during the first three months after starting therapy in men younger than 65 years old who had a history of heart disease. Similarly, the risk also doubled for all men older than 65 – those with or without heart disease – shortly after beginning treatment, according the study published in PLOS One.

At first blush, this may not seem to be heart-stopping news. Previous studies have suggested such therapies – including the widely touted AndroGel that is sold by AbbVie – can increase cardiovascular risk. In fact, a small study published in The New England Journal of Medicine three years ago reached such a conclusion (read this ).

But the latest study is different and, consequently, may have the potential to change the conversation about the extent to which using testosterone treatments is desirable. And the results are prompting calls for the FDA to update product labeling (see this , this and this ) in order to flag cardiovascular concerns.

Why? Unlike earlier efforts, the latest study examined a large population. The researchers culled records of 55,593 men who had been prescribed testosterone treatments, including 48,539 who were younger than 65 years old. The data was obtained from Truven Health Analytics, which aggregates patient records.

“Due to the size of our study, we were able to examine heart attacks, as opposed to a variety of cardiovascular conditions, and we were able to examine excess risk in the short term,” says William Finkle, the lead author and an epidemiologist at Consolidated Research, a statistics and software development firm. “Our study is also the first to include a substantial number of men under 65″ (here is the study ).

An AbbVie spokesman did not respond to a request for comment.

The researchers also compared patients given testosterone treatments – which include the Axiron solution sold by Eli Lilly and the Androderm patch marketed by Actavis – with those given the Viagra and Cialis erectile dysfunction pills, since these are similarly prescribed for enhancing sexual performance.

Here, they found that men younger than 65 who were given testosterone boosters and had a history of heart disease were twice as likely to suffer a heart attack, relative to the impotence pills. The implication is that the increase in cardiovascular risk is due to the treatments, not the sexual behavior.

The findings come amid years of aggressive promotion of testosterone treatments. A study published last fall in the Journal of the American Medical Association noted that annual prescriptions for these elixirs rose more than five-fold from 2000 to 2011, reaching 5.3 million prescriptions. Sales totaled nearly $2 billion in 2012, according to IMS Health , the research firm.

The marketing has sometimes been controversial. Four years ago, a study in The New England Journal of Medicine found only 2 percent of men aged 40 to 80 suffered from ‘Low T,’ which is sometimes called male menopause, but the web site run by Abbott Laboratories (and now by AbbVie) was criticized for overstating the case.

And two years ago, a group of physicians and academics complained to the independent Pharmaceutical Advertising Advisory Board in Canada that an AndroGel campaign harmed public health by promoting unapproved uses and implying exaggerated effectiveness.

Consequently, the PLOS authors recommend further studies that can “assess the range of benefits and risks.” Although Sid Wolfe of Public Citizen Health Research Group believes the FDA should not wait to update the product labeling to reflect the risk of heart attacks.

“This study adds an enormous amount to what is known about the risks,” he argues. “It’s an important breakthrough and the implications are sobering, but unfortunately, there is nothing in the current labeling or the med guides for patients.”

Source: Forbes Business

 
Update
10

6 weeks ago

RM47mil KWSG contributions still unclaimed

Jun 9 2014 7:54am CDT | Source: Business Times Malaysia

Cambodia's Famous Battambang Circus
KUALA LUMPUR: About RM47 million of contributions in the Teachers Provident Fund (KWSG) still remain unclaimed, the Dewan Rakyat was told toda ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
9

6 weeks ago

Gold shop lost almost RM1mil

Jun 9 2014 3:50am CDT | Source: Business Times Malaysia

Melbourne Rising Media Launch
KANGAR: A gold shop owner lost almost RM1 million after after the safe on in his shop was broken into by ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
8

6 weeks ago

Motion to debate MAS losses in Dewan Rakyat rejected

Jun 9 2014 3:39am CDT | Source: Business Times Malaysia

Federal Aviation Administration Bans All US Flights To Israel
KUALA LUMPUR: AN emergency motion to debate the losses incurred by Malaysia Airlines last year, amounting to RM1.2 billion was rejected ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
7

6 weeks ago

MH370 Tragedy: Hisham: RM27.6 mil spent on 1st phase of SAR

Jun 9 2014 2:11am CDT | Source: Business Times Malaysia

KUALA LUMPUR: Malaysia spent some RM27.6 million in its first phase of the search operations for missing Malaysia Airline flight MH370, said Acting Transport Minister, Datuk S ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
6

6 weeks ago

9.1m litres of diesel seized in a month

Jun 8 2014 1:11am CDT | Source: Business Times Malaysia

INDIA-CHINA-DIPLOMACY-TRADE
PUTRAJAYA: The Domestic Trade, Cooperatives, and Consumerism ministry has seized some 9.1 million litres of diesel and property worth RM58 million since mounting ‘Operasi Diesel Selatan’ in ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
5

7 weeks ago

Girl, 9, awarded RM2.78m compensation for medical negligence

Jun 6 2014 4:56am CDT | Source: Business Times Malaysia

Government Weekly Cabinet Meeting
KUALA LUMPUR: A nine-year-old girl who suffered brain damage during her birth at a government hospital was awarded over RM2.78 million i ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
4

7 weeks ago

Malaysia's total trade in April up 12pc

Jun 5 2014 11:52pm CDT | Source: Business Times Malaysia

KUALA LUMPUR: Malaysia's total trade in April 2014 rose by 12 per cent from a year ago to RM123.86 billion due to growing trading activities, International Trade and Industry Minister Datuk Seri Mustapa ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
3

7 weeks ago

Works Ministry to spend RM20m for upgrading works at 50 accident black spots

Jun 4 2014 11:35pm CDT | Source: Business Times Malaysia

Iskandar Johor Open - Previews
JOHOR BARU: The Works Ministry will implement upgrading works at 50 accident prone locations in the country that have been identified this year involving an allocation of RM2 ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
2

7 weeks ago

Najib launches loan scheme for Ramadan traders

Jun 4 2014 10:24pm CDT | Source: Business Times Malaysia

EurAsia Cup presented by DRB-HICOM - Day One
PUTRAJAYA: Prime Minister Datuk Seri Najib Razak today launches RM45 million Ramadan Bazaar ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 
Update
1

7 weeks ago

Residents bring up objection against Kidex to Suhakam

Jun 4 2014 4:49am CDT | Source: Business Times Malaysia

PETALING JAYA: A group of 20 Petaling Jaya residents held a meeting with the Human Rights Commission of Malaysia (Suhakam) over their objection against the proposed RM2.2 billion Kinrara Damansara Skyway ...
Source: Business Times Malaysia   Full article at: Business Times Malaysia
 

 

Don't miss ...

 

<a href="/latest_stories/all/all/30" rel="author">Forbes</a>
Forbes is among the most trusted resources for the world's business and investment leaders, providing them the uncompromising commentary, concise analysis, relevant tools and real-time reporting they need to succeed at work, profit from investing and have fun with the rewards of winning.

 

blog comments powered by Disqus

Latest stories

UN body concerned about impact of Gaza violence on women
United Nations, July 26 (IANS) The United Nations Population Fund (UNFPA) Friday expressed its deep concern about the impact of the ongoing Gaza conflict on women's health and access to safe births.
 
 
DG: No survivor in Algerian plane crash, probe launched (Roundup)
Algiers/Paris, July 25 (IANS) Algeria Friday declared a three-day national morning for the victims of the Air Algerie flight AH 5017 that crashed over Mali the previous day with no survivor yet found from the plane wreckage, media reports said.
 
 
Earth missed solar catastrophe just a year back: NASA
Washington, July 25 (IANS) Just a year ago, on July 23, the Earth missed being hit by a giant solar flare from the most powerful storm on the sun in over 150 years, NASA has said in a sensational revelation.
 
 
McDonald's Japan withdraws chicken products of Chinese origin
Tokyo, July 25 (IANS/EFE) The Japanese subsidiary of McDonald's Friday announced the withdrawal of all its chicken products sourced from China, following the expired meat scandal that led to the closure of Chinese meat processing firm Husi.
 
 
 

Latest from the Network

Paris Jackson asked to reconnect with family
Los Angeles, July 26 (IANS) Late pop star Michael Jackson's daughter Paris, who has returned here from her boarding school in Utah, has been advised to reconnect with her family. After she made an attempt to take her...
Read more on Celebrity Balla
 
UN body concerned about impact of Gaza violence on women
United Nations, July 26 (IANS) The United Nations Population Fund (UNFPA) Friday expressed its deep concern about the impact of the ongoing Gaza conflict on women's health and access to safe births. "Reports of the...
Read more on Politics Balla
 
Kate Upton always wanted curvy figure
Kate Upton has always wanted a curvaceous figure. The 'Other Woman' star, 22, admits she ''begged'' for a shapely body when she first started modeling and was overjoyed when people started praising her sexy shape....
Read more on Celebrity Balla
 
Jenny McCarthy's son reported her to police
Jenny McCarthy's son called the police on her. The former Playboy model admits Evan, 12 - whom she has with ex-husband John Asher - once reported her for texting on her phone whilst she was driving. Speaking on Sirius...
Read more on Celebrity Balla
 
Jennifer Lopez 'danced all night' at 45th birthday bash
Jennifer Lopez ''danced all night long'' at her 45th birthday bash in the Hamptons last night (07.24.14). The 'I Luh Ya Papi' hitmaker spent the duration of her party on the dance floor at Nammos, a Mediterranean...
Read more on Celebrity Balla
 
Scott Disick won't drink alcohol until after birth
Scott Disick reportedly won't drink alcohol until after the birth of his third child later this year. The 31-year-old reality TV star - the long-time partner of Kourtney Kardashian - is determined to stay sober after...
Read more on Celebrity Balla
 
Love the idea of lots of kids: Radcliffe
New York, July 26 (IANS) If Daniel Radcliffe had his way, he'd have "lots of kids" in the years to come. "Maybe because I'm an only child, I love the idea of lots of kids. But it will depend to a larger part on who I...
Read more on Celebrity Balla
 
Kyrgyz ex-president sentenced to life imprisonment
Bishkek, July 26 (IANS) A Kyrgyz military court Friday sentenced in absentia the country's former president Kurmanbek Bakiyev, his brother Janysh Bakiyev and former prime minister Daniyar Usenov to life imprisonment....
Read more on Politics Balla
 
Why Lily Allen goes into shutdown mode?
Los Angeles, July 26 (IANS) Singer Lily Allen has decided to go into shutdown mode after receiving criticism on a social networking site. Allen says this is her way of coping with backlash, reports mirror.co.uk. The...
Read more on Celebrity Balla
 
ASUS MeMO Pad 7 Intel Bay Trail Tablet Shows Serious Android On X86 Value
Low cost tablets have been a goal for a long time now but breaking the $200 mark hasn’t been easy for manufacturers, without sacrificing features and quality.  Then again, what if I told you there’s a 7-inch tablet on...
Read more on Apple Balla